![Anti-CD23 antibody [MRQ-57] (STJ16100453)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149170/346796/STJ16100453_1__80371.1681998898.jpg?c=1 "Anti-CD23 antibody [MRQ-57] (STJ16100453)")
![Anti-CD23 antibody [MRQ-57] (STJ16100453)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149170/346796/STJ16100453_1__80371.1681998898.jpg?c=1 "Anti-CD23 antibody [MRQ-57] (STJ16100453)")
| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-CD23 is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | MRQ-57 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Dilution Range: | IHC 1:100 – 1:500 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Background | CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas. Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL). |
Information sourced from Uniprot.org
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