Anti-CD222 antibody [MEM-238] (STJ16100179)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant Vaccinia virus encoding CD222.
General Information
| Short Description | Mouse monoclonal anti-CD222 for use in FC, IP and WB in Non-Human Primates and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IP/WB |
| Host | Mouse |
| Reactivity | Non-Human Primates/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MEM-238 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Formulation | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Recombinant Vaccinia virus encoding CD222. |
Additional Info
| Background | CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor) , plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria. |
Information sourced from Uniprot.org