• Immunohistochemistry analysis of paraffin embedded human tonsil using CD21 at dilution of 1:100

Anti-CD21 antibody [SM5143] (STJA0005143)

SKU:
STJA0005143-50

£233.50
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Host: Mouse
Applications: IHC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD21 is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: SM5143
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range: IHC/IF (H) 1:200-1:500
Storage Instruction: Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.
Gene Symbol: CR2
Gene ID: 1380
Uniprot ID: CR2_HUMAN
Immunogen: Synthesized peptide derived from human CD21
Function Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Induces also specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production. (Microbial infection) Acts as a receptor for Epstein-Barr virus.
Protein Name Complement Receptor Type 2
Cr2
Complement C3d Receptor
Epstein-Barr Virus Receptor
Ebv Receptor
Cd Antigen Cd21
Database Links Reactome: R-HSA-977606
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Complement Receptor Type 2 antibody
Anti-Cr2 antibody
Anti-Complement C3d Receptor antibody
Anti-Epstein-Barr Virus Receptor antibody
Anti-Ebv Receptor antibody
Anti-Cd Antigen Cd21 antibody
Anti-CR2 antibody
Anti-C3DR antibody

Information sourced from Uniprot.org

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