| Tissue Specificity | Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells. |
| Function | Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. |
| Protein Name | Cell Surface Glycoprotein Cd200 Receptor 1Cd200 Cell Surface Glycoprotein ReceptorCell Surface Glycoprotein Ox2 Receptor 1 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 4: Cell MembraneIsoform 2: SecretedIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Cell Surface Glycoprotein Cd200 Receptor 1 antibodyAnti-Cd200 Cell Surface Glycoprotein Receptor antibodyAnti-Cell Surface Glycoprotein Ox2 Receptor 1 antibodyAnti-CD200R1 antibodyAnti-CD200R antibodyAnti-CRTR2 antibodyAnti-MOX2R antibodyAnti-OX2R antibodyAnti-UNQ2522 antibodyAnti-PRO6015 antibody |
Information sourced from Uniprot.org
