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Anti-CD19 antibody [2E2B6B10] (STJ97910)

Immunohistochemistry analysis of paraffin-embedded human normal lymph node, showing cytoplasmic localization with DAB staining using CD19 monoclonal antibody.
Western blot analysis using CD19 monoclonal antibody against CD19 recombinant protein.

Anti-CD19 antibody [2E2B6B10] (STJ97910)

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STJ97910

£139.00 - £336.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-B-lymphocyte antigen CD19 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Monoclonal
Clone ID:	2E2B6B10
Conjugation:	Unconjugated
Isotype:	IgG2a
Formulation:	Liquid in PBS containing 0.03% Sodium Azide.
Purification:	Affinity purification
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:200-1:1000 ELISA 1:10000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD19
Gene ID:	930
Uniprot ID:	CD19_HUMAN
Specificity:	CD19 Monoclonal Antibody detects endogenous levels of CD19 protein.
Immunogen:	Purified recombinant fragment of human CD19 expressed in E. Coli.

Post Translational Modifications	Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels.
Function	Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
Protein Name	B-Lymphocyte Antigen Cd19 B-Lymphocyte Surface Antigen B4 Differentiation Antigen Cd19 T-Cell Surface Antigen Leu-12 Cd Antigen Cd19
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-198933 Reactome: R-HSA-2219530 Reactome: R-HSA-6811558 Reactome: R-HSA-977606 Reactome: R-HSA-983695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft
Alternative Antibody Names	Anti-B-Lymphocyte Antigen Cd19 antibody Anti-B-Lymphocyte Surface Antigen B4 antibody Anti-Differentiation Antigen Cd19 antibody Anti-T-Cell Surface Antigen Leu-12 antibody Anti-Cd Antigen Cd19 antibody Anti-CD19 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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