Host: | Armenian Hamster |
Applications: | FC |
Reactivity: | Mouse |
Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Short Description: | Armenian Hamster monoclonal antibody anti-C-X-C chemokine receptor type 3 is suitable for use in Flow Cytometry research applications. |
Clonality: | Monoclonal |
Clone ID: | CXCR3-173 |
Conjugation: | PE/Cyanine5.5 |
Isotype: | IgG |
Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Concentration: | 0.2 mg/mL |
Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Gene Symbol: | Cxcr3 |
Gene ID: | 12766 |
Uniprot ID: | CXCR3_MOUSE |
Tissue Specificity | Expresses in lymphoid organs and Th1 cells. |
Post Translational Modifications | Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding. N-glycosylated. |
Function | Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. |
Protein Name | C-X-C Chemokine Receptor Type 3 Cxc-R3 Cxcr-3 Interferon-Inducible Protein 10 Receptor Ip-10 Receptor Cd Antigen Cd183 |
Database Links | Reactome: R-MMU-380108 Reactome: -MMU-418594 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
Alternative Antibody Names | Anti-C-X-C Chemokine Receptor Type 3 antibody Anti-Cxc-R3 antibody Anti-Cxcr-3 antibody Anti-Interferon-Inducible Protein 10 Receptor antibody Anti-Ip-10 Receptor antibody Anti-Cd Antigen Cd183 antibody Anti-Cxcr3 antibody Anti-Cmkar3 antibody |
Information sourced from Uniprot.org