Anti-CD18/Itgb2 antibody [M18/2] {PE} (STJA0001724)

SKU:
STJA0001724

£114.50 - £179.50
Current Stock:
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Integrin beta-2 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: M18/2
Conjugation: PE
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Concentration: 0.2 mg/mL
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Itgb2
Gene ID: 16414
Uniprot ID: ITB2_MOUSE
Post Translational Modifications Both Ser-747 and Ser-758 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-760 (but not on Ser-758) allows interaction with 14-3-3 proteins.
Function Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. Integrin ITGAM/ITGB2 plays a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the ITGAM subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity.
Protein Name Integrin Beta-2
Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit Beta
Complement Receptor C3 Subunit Beta
Cd Antigen Cd18
Database Links Reactome: R-MMU-166016
Reactome: -MMU-198933
Reactome: -MMU-202733
Reactome: -MMU-216083
Reactome: -MMU-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Alternative Antibody Names Anti-Integrin Beta-2 antibody
Anti-Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit Beta antibody
Anti-Complement Receptor C3 Subunit Beta antibody
Anti-Cd Antigen Cd18 antibody
Anti-Itgb2 antibody

Information sourced from Uniprot.org

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