Host: | Rat |
Applications: | FC |
Reactivity: | Mouse |
Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Short Description: | Rat monoclonal antibody anti-Integrin beta-2 is suitable for use in Flow Cytometry research applications. |
Clonality: | Monoclonal |
Clone ID: | M18/2 |
Conjugation: | PE/Cyanine7 |
Isotype: | IgG2ak |
Formulation: | PBS with 0.05% Proclin300, 1% BSA |
Concentration: | 0.2 mg/mL |
Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Gene Symbol: | Itgb2 |
Gene ID: | 16414 |
Uniprot ID: | ITB2_MOUSE |
Post Translational Modifications | Both Ser-747 and Ser-758 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-760 (but not on Ser-758) allows interaction with 14-3-3 proteins. |
Function | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. Integrin ITGAM/ITGB2 plays a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the ITGAM subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity. |
Protein Name | Integrin Beta-2 Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit Beta Complement Receptor C3 Subunit Beta Cd Antigen Cd18 |
Database Links | Reactome: R-MMU-166016 Reactome: -MMU-198933 Reactome: -MMU-202733 Reactome: -MMU-216083 Reactome: -MMU-6798695 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft |
Alternative Antibody Names | Anti-Integrin Beta-2 antibody Anti-Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit Beta antibody Anti-Complement Receptor C3 Subunit Beta antibody Anti-Cd Antigen Cd18 antibody Anti-Itgb2 antibody |
Information sourced from Uniprot.org