Anti-CD177 antibody [SRM13447] (STJ11108177)

SKU:
STJ11108177
£0.00
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: FC/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : SRM13447
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS containing 50% Glycerol and 0.05% BSA, preserved with proclin300 or Sodium Azide (as specified on the Certificate of Analysis) , pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: FC, 1:100-1:500
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD177
Gene ID: 57126
Uniprot ID: CD177_HUMAN
Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Immunogen Sequence: Human
Post Translational Modifications N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding).
Function In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis.
Protein Name Cd177 Antigen
Human Neutrophil Alloantigen 2a
Hna-2a
Nb1 Glycoprotein
Nb1 Gp
Polycythemia Rubra Vera Protein 1
Prv-1
Cd Antigen Cd177
Database Links Reactome: R-HSA-140875
Reactome: R-HSA-202733
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Membrane Raft
Gpi-Like-Anchor
Secreted
Cytoplasmic Granule Membrane
Cell Projection
Lamellipodium
Cell Surface Expression On Neutrophils Is Increased Upon Tnf-Alpha
Fmlp Or Cxcl8/Il8-Mediated Stimulation
In Neutrophils
Stored Predominantly In Secondary And Tertiary Granules
Can Also Be Shedded From The Cell Membrane
Localizes To Lamellar Protrusions In Spreading Neutrophils
Alternative Antibody Names Anti-Cd177 Antigen antibody
Anti-Human Neutrophil Alloantigen 2a antibody
Anti-Hna-2a antibody
Anti-Nb1 Glycoprotein antibody
Anti-Nb1 Gp antibody
Anti-Polycythemia Rubra Vera Protein 1 antibody
Anti-Prv-1 antibody
Anti-Cd Antigen Cd177 antibody
Anti-CD177 antibody
Anti-NB1 antibody
Anti-PRV1 antibody
Anti-UNQ595 antibody
Anti-PRO1181 antibody

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ11109466 Anti-CD177 antibody [SRM14736] (STJ11109466) Rabbit Monoclonal Human WB/IHC-P/ELISA
STJ28633 Anti-CD177 antibody (35-285) (STJ28633) Rabbit Polyclonal Human/Mouse WB/ELISA
STJ16100178 Anti-CD177 antibody [MEM-166] (STJ16100178) Mouse Monoclonal Non-Human Primates/Human FC/IP/WB
STJ11108673 Anti-CD177 antibody {ABflo® 488} (STJ11108673) Rabbit Monoclonal Human FC

Related Products

!