![Anti-CD16b/FCGR3B nanobody [C21] (STJN000594)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/201207/413305/STJN000594-SDS-PAGE-1__00972.1749232781.jpg?c=1 "Anti-CD16b/FCGR3B nanobody [C21] (STJN000594)")
![Anti-CD16b/FCGR3B nanobody [C21] (STJN000594)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/201207/413305/STJN000594-SDS-PAGE-1__00972.1749232781.jpg?c=1 "Anti-CD16b/FCGR3B nanobody [C21] (STJN000594)")
Anti-CD16b/FCGR3B nanobody [C21] (STJN000594)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B is suitable for use in ELISA and FuncS research applications. |
| Applications | ELISA/FuncS |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | C21 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | FCGR3B |
| Gene ID | 2215 |
| Uniprot ID | FCG3B_HUMAN |
Additional Info
| Post Translational Modifications | Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage. |
| Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-BFc-Gamma Riii-BetaCd16-IFc-Gamma RiiiFc-Gamma RiiibFcriiiFcriiibFcr-10Igg Fc Receptor Iii-1Cd Antigen Cd16b |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSecreted After Cleavage |
| Alternative Nanobody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B nanobodyAnti-Fc-Gamma Riii-Beta nanobodyAnti-Cd16-I nanobodyAnti-Fc-Gamma Riii nanobodyAnti-Fc-Gamma Riiib nanobodyAnti-Fcriii nanobodyAnti-Fcriiib nanobodyAnti-Fcr-10 nanobodyAnti-Igg Fc Receptor Iii-1 nanobodyAnti-Cd Antigen Cd16b nanobodyAnti-FCGR3B nanobodyAnti-CD16B nanobodyAnti-FCG3 nanobodyAnti-FCGR3 nanobodyAnti-IGFR3 nanobody |
Information sourced from Uniprot.org