![Anti-CD152/CTLA4 nanobody [SAA0918] (STJN000161)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200774/412956/STJN000161-SDS-PAGE-1__71344.1749232484.jpg?c=1 "Anti-CD152/CTLA4 nanobody [SAA0918] (STJN000161)")
![Anti-CD152/CTLA4 nanobody [SAA0918] (STJN000161)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200774/412956/STJN000161-SDS-PAGE-1__71344.1749232484.jpg?c=1 "Anti-CD152/CTLA4 nanobody [SAA0918] (STJN000161)")
Anti-CD152/CTLA4 nanobody [SAA0918] (STJN000161)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Cytotoxic T-Lymphocyte Protein 4 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0918 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | CTLA4 |
| Gene ID | 1493 |
| Uniprot ID | CTLA4_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. |
| Function | Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. |
| Protein Name | Cytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Ctla-4Cd Antigen Cd152 |
| Database Links | Reactome: R-HSA-389356Reactome: R-HSA-389513Reactome: R-HSA-8877330 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinExists Primarily An Intracellular Antigen Whose Surface Expression Is Tightly Regulated By Restricted Trafficking To The Cell Surface And Rapid Internalization |
| Alternative Nanobody Names | Anti-Cytotoxic T-Lymphocyte Protein 4 nanobodyAnti-Cytotoxic T-Lymphocyte-Associated Antigen 4 nanobodyAnti-Ctla-4 nanobodyAnti-Cd Antigen Cd152 nanobodyAnti-CTLA4 nanobodyAnti-CD152 nanobody |
Information sourced from Uniprot.org