• Western blot with Anti-CD146 Antibody (STJ501819)of rat lung at 1:500 dilution in buffer.

Anti-CD146 antibody (330-353) (STJ501819)

SKU:
STJ501819-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CD146 (330-353) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Mcam
Gene ID: 78967
Uniprot ID: MUC18_RAT
Immunogen Region: 330-353
Immunogen: Synthetic peptide taken within amino acid region 330-353 on rat Cell Surface Glycoprotein MUC18 protein.
Tissue Specificity Detected in lung, uterus and placenta (at protein level). Detected in heart, lung, kidney, adrenal gland, intestine, testis, skeletal muscle and aorta. Detected at low levels in adult brain, in particular in brain stem and spinal cord, but also in hippocampus, olfactory bulb and striatum (at protein level).
Function Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Protein Name Cell Surface Glycoprotein Muc18
Gicerin
Melanoma Cell Adhesion Molecule
Melanoma-Associated Antigen Muc18
Cd Antigen Cd146
Database Links Reactome: R-RNO-8980692
Reactome: -RNO-9013026
Reactome: -RNO-9013106
Reactome: -RNO-9013149
Reactome: -RNO-9013404
Reactome: -RNO-9013405
Reactome: -RNO-9013408
Reactome: -RNO-9013423
Reactome: -RNO-9035034
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Perikaryon
Detected At The Surface Of The Cell Body Of Motor Neurons
Alternative Antibody Names Anti-Cell Surface Glycoprotein Muc18 antibody
Anti-Gicerin antibody
Anti-Melanoma Cell Adhesion Molecule antibody
Anti-Melanoma-Associated Antigen Muc18 antibody
Anti-Cd Antigen Cd146 antibody
Anti-Mcam antibody
Anti-Muc18 antibody

Information sourced from Uniprot.org

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