| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CD146 (330-353) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5-1.5 µg/µl |
| Dilution Range: |
WB: 1:2, 500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Mcam |
| Gene ID: |
78967 |
| Uniprot ID: |
MUC18_RAT |
| Immunogen Region: |
330-353 |
| Immunogen: |
Synthetic peptide taken within amino acid region 330-353 on rat Cell Surface Glycoprotein MUC18 protein. |
| Tissue Specificity | Detected in lung, uterus and placenta (at protein level). Detected in heart, lung, kidney, adrenal gland, intestine, testis, skeletal muscle and aorta. Detected at low levels in adult brain, in particular in brain stem and spinal cord, but also in hippocampus, olfactory bulb and striatum (at protein level). |
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Protein Name | Cell Surface Glycoprotein Muc18GicerinMelanoma Cell Adhesion MoleculeMelanoma-Associated Antigen Muc18Cd Antigen Cd146 |
| Database Links | Reactome: R-RNO-8980692Reactome: -RNO-9013026Reactome: -RNO-9013106Reactome: -RNO-9013149Reactome: -RNO-9013404Reactome: -RNO-9013405Reactome: -RNO-9013408Reactome: -RNO-9013423Reactome: -RNO-9035034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPerikaryonDetected At The Surface Of The Cell Body Of Motor Neurons |
| Alternative Antibody Names | Anti-Cell Surface Glycoprotein Muc18 antibodyAnti-Gicerin antibodyAnti-Melanoma Cell Adhesion Molecule antibodyAnti-Melanoma-Associated Antigen Muc18 antibodyAnti-Cd Antigen Cd146 antibodyAnti-Mcam antibodyAnti-Muc18 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
