Anti-CD124/IL4R/IL-4R Alpha nanobody [SAA1420] (STJN000528)

Anti-CD124/IL4R/IL-4R Alpha nanobody [SAA1420] (STJN000528)

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STJN000528
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Interleukin-4 Receptor Subunit Alpha is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1420
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: IL4R
Gene ID: 3566
Uniprot ID: IL4RA_HUMAN
Post Translational Modifications On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.
Function Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Protein Name Interleukin-4 Receptor Subunit Alpha
Il-4 Receptor Subunit Alpha
Il-4r Subunit Alpha
Il-4r-Alpha
Il-4ra
Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha
Soluble Il-4 Receptor Subunit Alpha
Soluble Il-4r-Alpha
Sil4ralpha/Prot
Il-4-Binding Protein
Il4-Bp
Database Links Reactome: R-HSA-6785807
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Nanobody Names Anti-Interleukin-4 Receptor Subunit Alpha nanobody
Anti-Il-4 Receptor Subunit Alpha nanobody
Anti-Il-4r Subunit Alpha nanobody
Anti-Il-4r-Alpha nanobody
Anti-Il-4ra nanobody
Anti-Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha nanobody
Anti-Soluble Il-4 Receptor Subunit Alpha nanobody
Anti-Soluble Il-4r-Alpha nanobody
Anti-Sil4ralpha/Prot nanobody
Anti-Il-4-Binding Protein nanobody
Anti-Il4-Bp nanobody
Anti-IL4R nanobody
Anti-IL4RA nanobody
Anti-582J2.1 nanobody

Information sourced from Uniprot.org

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