Anti-CD124/IL4R antibody [Fs0362] (STJA0032148)

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STJA0032148-100
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Short Description :Rat monoclonal anti-CD124/IL4R for use in ELISA, FCM and Neut in Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:ELISA/FCM/Neut
Host:Rat
Reactivity:Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :Fs0362
Isotype:IgG1
Conjugation:Unconjugated
Purification:Protein A/G purified from cell culture supernatant
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Endotoxin:Please contact us for this information.
Gene Symbol:Il4r
Gene ID:25084
Uniprot ID:IL4RA_RAT
Post Translational Modifications On IL4 binding, phosphorylated on C-terminal tyrosine residues.
Function Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation.
Protein Name Interleukin-4 Receptor Subunit Alpha
Il-4 Receptor Subunit Alpha
Il-4r Subunit Alpha
Il-4r-Alpha
Il-4ra
Cd Antigen Cd124
Database Links Reactome: R-RNO-6785807
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Antibody Names Anti-Interleukin-4 Receptor Subunit Alpha antibody
Anti-Il-4 Receptor Subunit Alpha antibody
Anti-Il-4r Subunit Alpha antibody
Anti-Il-4r-Alpha antibody
Anti-Il-4ra antibody
Anti-Cd Antigen Cd124 antibody
Anti-Il4r antibody
Anti-Il4ra antibody

Information sourced from Uniprot.org

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