| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Interleukin-3 receptor subunit alpha is suitable for use in Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 6H6 |
| Conjugation: | PerCP/Cyanine5.5 |
| Isotype: | IgG1k |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Concentration: | 5 Mu L/Test |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | IL3RA |
| Gene ID: | 3563 |
| Uniprot ID: | IL3RA_HUMAN |
| Post Translational Modifications | Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. |
| Function | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. |
| Protein Name | Interleukin-3 Receptor Subunit Alpha Il-3 Receptor Subunit Alpha Il-3r Subunit Alpha Il-3r-Alpha Il-3ra Cd Antigen Cd123 |
| Database Links | Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-912526 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-3 Receptor Subunit Alpha antibody Anti-Il-3 Receptor Subunit Alpha antibody Anti-Il-3r Subunit Alpha antibody Anti-Il-3r-Alpha antibody Anti-Il-3ra antibody Anti-Cd Antigen Cd123 antibody Anti-IL3RA antibody Anti-IL3R antibody |
Information sourced from Uniprot.org