Anti-CD120a/TNFRSF1A/TNFR1 nanobody [SAA1242] (STJN000167)

Anti-CD120a/TNFRSF1A/TNFR1 nanobody [SAA1242] (STJN000167)

SKU:
STJN000167
£378.50 - £1,632.50
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Tumor Necrosis Factor Receptor Superfamily Member 1a is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1242
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: TNFRSF1A
Gene ID: 7132
Uniprot ID: TNR1A_HUMAN
Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 1a
Tumor Necrosis Factor Receptor 1
Tnf-R1
Tumor Necrosis Factor Receptor Type I
Tnf-Ri
Tnfr-I
P55
P60
Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1
Tbpi
Database Links Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-5626978
Reactome: R-HSA-5669034
Reactome: R-HSA-6783783
Reactome: R-HSA-75893
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus Membrane
Secreted
A Secreted Form Is Produced Through Proteolytic Processing
Isoform 4: Secreted
Lacks A Golgi-Retention Motif
Is Not Membrane Bound And Therefore Is Secreted
Alternative Nanobody Names Anti-Tumor Necrosis Factor Receptor Superfamily Member 1a nanobody
Anti-Tumor Necrosis Factor Receptor 1 nanobody
Anti-Tnf-R1 nanobody
Anti-Tumor Necrosis Factor Receptor Type I nanobody
Anti-Tnf-Ri nanobody
Anti-Tnfr-I nanobody
Anti-P55 nanobody
Anti-P60 nanobody
Anti-Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 nanobody
Anti-Tbpi nanobody
Anti-TNFRSF1A nanobody
Anti-TNFAR nanobody
Anti-TNFR1 nanobody

Information sourced from Uniprot.org

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