| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Itgam |
| Uniprot ID: |
ITAM_MOUSE |
| Immunogen Region: |
143-337 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 143-337 of mouse CD11b (NP_032427.2). |
| Immunogen Sequence: |
ECPQQESDIVFLIDGSGSIN NIDFQKMKEFVSTVMEQFKK SKTLFSLMQYSDEFRIHFTF NDFKRNPSPRSHVSPIKQLN GRTKTASGIRKVVRELFHKT NGARENAAKILVVITDGEKF GDPLDYKDVIPEADRAGVIR YVIGVGNAFNKPQSRRELDT IASKPAGEHVFQVDNFEALN TIQNQLQEKIFAIEG |
| Tissue Specificity | Predominantly expressed in monocytes and granulocytes. Expressed in a subset of peritoneal mast cells. Expressed in microglia (at protein level). |
| Function | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
| Protein Name | Integrin Alpha-MCd11 Antigen-Like Family Member BCr-3 Alpha ChainCell Surface Glycoprotein Mac-1 Subunit AlphaLeukocyte Adhesion Receptor Mo1Cd Antigen Cd11b |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Antibody Names | Anti-Integrin Alpha-M antibodyAnti-Cd11 Antigen-Like Family Member B antibodyAnti-Cr-3 Alpha Chain antibodyAnti-Cell Surface Glycoprotein Mac-1 Subunit Alpha antibodyAnti-Leukocyte Adhesion Receptor Mo1 antibodyAnti-Cd Antigen Cd11b antibodyAnti-Itgam antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
