Anti-CD119/Ifngr1 antibody [GR-20] {PE} (STJA0001740)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationPE
IsotypeIgG2ak
General Information
| Short Description | Rat monoclonal anti-Interferon gamma receptor 1 for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rat |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | GR-20 |
| Isotype | IgG2ak |
| Conjugation | PE |
| Concentration | 0.2 mg/mL |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8ยฐC and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | Ifngr1 |
| Gene ID | 15979 |
| Uniprot ID | INGR1_MOUSE |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser/Thr residues. Phosphorylation of Tyr-445 is required for IFNG receptor signal transduction. Influenza virus infection leads to phosphorylation in a CSNK1A1-dependent manner. Ubiquitinated after phosphorylation in a CSNK1A1-dependent manner, leading to the lysosome-dependent degradation. Proteasomally degraded through 'Lys-48'-mediated ubiquitination. Ubiquitination is necessary for efficient IFNGR1 signaling. |
| Function | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1. |
| Protein Name | Interferon Gamma Receptor 1Ifn-Gamma Receptor 1Ifn-Gamma-R1Interferon Gamma Receptor Alpha-ChainIfn-Gamma-R-AlphaCd Antigen Cd119 |
| Database Links | Reactome: R-MMU-877300Reactome: -MMU-877312Reactome: -MMU-9732724 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interferon Gamma Receptor 1 antibodyAnti-Ifn-Gamma Receptor 1 antibodyAnti-Ifn-Gamma-R1 antibodyAnti-Interferon Gamma Receptor Alpha-Chain antibodyAnti-Ifn-Gamma-R-Alpha antibodyAnti-Cd Antigen Cd119 antibodyAnti-Ifngr1 antibodyAnti-Ifngr antibody |
Information sourced from Uniprot.org