| Short Description : | Rabbit monoclonal Cd109 antigen (223-462 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5222RM |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD109 |
| Gene ID: | 135228 |
| Uniprot ID: | CD109_HUMAN |
| Immunogen Region: | 223-462 aa |
| Immunogen Sequence: | EYVLPKFEVTLQTPLYCSMN SKHLNGTITAKYTYGKPVKG DVTLTFLPLSFWGKKKNITK TFKINGSANFSFNDEEMKNV MDSSNGLSEYLDLSSPGPVE ILTTVTESVTGISRNVSTNV FFKQHDYIIEFFDYTTVLKP SLNFTATVKVTRADGNQLTL EERRNNVVITVTQRNYTEYW SGSNSGNQKMEAVQKINYTV PQSGTFKIEFPILEDSSELQ LKAYFLGSKSSMAVHSLFK |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 223-462 of human CD109. (NP_598000.2). |
| Tissue Specificity | Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta. |
| Post Translational Modifications | N-glycosylated. 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form. |
| Function | Modulates negatively TGFB1 signaling in keratinocytes. |
| Protein Name | Cd109 Antigen150 Kda Tgf-Beta-1-Binding ProteinC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 7Platelet-Specific Gov AntigenP180R150Cd Antigen Cd109 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Cd109 Antigen antibodyAnti-150 Kda Tgf-Beta-1-Binding Protein antibodyAnti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 7 antibodyAnti-Platelet-Specific Gov Antigen antibodyAnti-P180 antibodyAnti-R150 antibodyAnti-Cd Antigen Cd109 antibodyAnti-CD109 antibodyAnti-CPAMD7 antibody |
Information sourced from Uniprot.org
