Anti-CACNA1H antibody (462-511 aa) (STJ96138)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CACNA1H at the amino acid range 462-511
General Information
| Short Description | Rabbit polyclonal anti-Voltage-dependent T-type calcium channel subunit alpha-1H (462-511 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CACNA1H |
| Gene ID | 8912 |
| Uniprot ID | CAC1H_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CACNA1H at the amino acid range 462-511 |
| Immunogen Region | 462-511 aa |
| Specificity | T-type Ca++ CP Alpha 1H Polyclonal Antibody detects endogenous levels of T-type Ca++ CP Alpha 1H protein. |
Additional Info
| Post Translational Modifications | In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. |
| Function | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia. |
| Protein Name | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1hLow-Voltage-Activated Calcium Channel Alpha1 3.2 SubunitVoltage-Gated Calcium Channel Subunit Alpha Cav3.2 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-445355Reactome: R-HSA-9856532 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInteraction With Stac Increases Expression At The Cell Membrane |
| Alternative Antibody Names | Anti-Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1h antibodyAnti-Low-Voltage-Activated Calcium Channel Alpha1 3.2 Subunit antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav3.2 antibodyAnti-CACNA1H antibody |
Information sourced from Uniprot.org