| Short Description : | Mouse monoclonal anti-Vascular Cell Adhesion Protein 1 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | FOR RESEARCH USE ONLY (RUO). |
| Clonality : | Monoclonal |
| Clone ID : | B-K9 |
| Isotype: | IgG1 |
| Conjugation: | FITC |
| Purification: | Protein A purification |
| Dilution Range: | Please carry out application specific titration to determine the most appropriate dilution ratio. |
| Formulation: | PBS with 0.2% BSA, and 0.09% Sodium Azide |
| Storage Instruction: | Shipped on gel ice packs. Store at 2-8C on arrival. |
| Gene Symbol: | VCAM1 |
| Gene ID: | 7412 |
| Uniprot ID: | VCAM1_HUMAN |
| Post Translational Modifications | Cleaved by the metalloproteinase ADAM17 to generate the soluble form. Sialoglycoprotein. Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination.leading to proteasomal degradation. |
| Function | Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation. |
| Protein Name | Vascular Cell Adhesion Protein 1V-Cam 1Vcam-1Incam-100Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-216083Reactome: R-HSA-6785807Reactome: R-HSA-877300 |
| Cellular Localisation | Vascular Cell Adhesion Protein 1: Cell MembraneSingle-Pass Type I Membrane ProteinSoluble Vascular Cell Adhesion Molecule-1: Secreted |
| Alternative Antibody Names | Anti-Vascular Cell Adhesion Protein 1 antibodyAnti-V-Cam 1 antibodyAnti-Vcam-1 antibodyAnti-Incam-100 antibodyAnti-Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1 antibodyAnti-VCAM1 antibody |
Information sourced from Uniprot.org
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