Anti-CD104/ITGB4 antibody [65A12] (STJA0026932)

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STJA0026932-100
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Short Description :Mouse monoclonal Integrin Beta-4 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :65A12
Isotype:IgG1k
Conjugation:Unconjugated
Concentration:1.48 mg/ml
Purification:Protein A/G purified from cell culture supernatant.
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol:ITGB4
Gene ID:3691
Uniprot ID:ITB4_HUMAN
Post Translational Modifications Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins.
Function Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
Protein Name Integrin Beta-4
Gp150
Cd Antigen Cd104
Database Links Reactome: R-HSA-2022090
Reactome: R-HSA-3000157
Reactome: R-HSA-3000170
Reactome: R-HSA-446107
Reactome: R-HSA-9725554
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Lipid-Anchor
Cell Junction
Hemidesmosome
Colocalizes With Dst At The Leading Edge Of Migrating Keratinocytes
Alternative Antibody Names Anti-Integrin Beta-4 antibody
Anti-Gp150 antibody
Anti-Cd Antigen Cd104 antibody
Anti-ITGB4 antibody

Information sourced from Uniprot.org

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