| Function | Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall. |
| Protein Name | Integrin Alpha-EIntegrin Alpha M290Cd Antigen Cd103 Cleaved Into - Integrin Alpha-E Light Chain - Integrin Alpha-E Heavy Chain |
| Database Links | Reactome: R-MMU-216083 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-E antibodyAnti-Integrin Alpha M290 antibodyAnti-Cd Antigen Cd103 Cleaved Into - Integrin Alpha-E Light Chain - Integrin Alpha-E Heavy Chain antibodyAnti-Itgae antibody |
Information sourced from Uniprot.org
![C57BL/6 murine splenocytes were stained with Anti-CD103 antibody (STJA0000463) [Used at 0.2 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/145316/291979/STJA0000463_1__67309.1631205802.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-CD103 antibody (STJA0000463) [Used at 0.2 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.")
