| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCT8 |
| Gene ID: | 10694 |
| Uniprot ID: | TCPQ_HUMAN |
| Immunogen Region: | 248-497 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 248-497 of human CCT8 (NP_001269837.1). |
| Immunogen Sequence: | DMALHYANKYNIMLVRLNSK WDLRRLCKTVGATALPRLTP PVLEEMGHCDSVYLSEVGDT QVVVFKHEKEDGAISTIVLR GSTDNLMDDIERAVDDGVNT FKVLTRDKRLVPGGGATEIE LAKQITSYGETCPGLEQYAI KKFAEAFEAIPRALAENSGV KANEVISKLYAVHQEGNKNV GLDIEAEVPAVKDMLEAGIL DTYLGKYWAIKLATNAAVTV LRVDQIIMAKPAGGPKPPS |
| Function | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable). |
| Protein Name | T-Complex Protein 1 Subunit ThetaTcp-1-ThetaCct-ThetaChaperonin Containing T-Complex Polypeptide 1 Subunit 8Renal Carcinoma Antigen Ny-Ren-15 |
| Database Links | Reactome: R-HSA-389957Reactome: R-HSA-389960Reactome: R-HSA-390450Reactome: R-HSA-390471Reactome: R-HSA-5620922Reactome: R-HSA-6798695Reactome: R-HSA-6814122 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCilium Basal Body |
| Alternative Antibody Names | Anti-T-Complex Protein 1 Subunit Theta antibodyAnti-Tcp-1-Theta antibodyAnti-Cct-Theta antibodyAnti-Chaperonin Containing T-Complex Polypeptide 1 Subunit 8 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-15 antibodyAnti-CCT8 antibodyAnti-C21orf112 antibodyAnti-CCTQ antibodyAnti-KIAA0002 antibody |
Information sourced from Uniprot.org