| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Centriolar coiled-coil protein of 110 kDa (850-900 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCP110 |
| Gene ID: |
9738 |
| Uniprot ID: |
CP110_HUMAN |
| Immunogen Region: |
850-900 aa |
| Specificity: |
Centriolin Polyclonal Antibody detects endogenous levels of Centriolin protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CEP110 at the amino acid range 850-900 |
| Post Translational Modifications | Phosphorylated by CDKs. Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. |
| Function | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. |
| Protein Name | Centriolar Coiled-Coil Protein Of 110 KdaCentrosomal Protein Of 110 KdaCp110Cep110 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-5689880Reactome: R-HSA-8854518Reactome: R-HSA-9013424 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCilium Basal BodyRecruited Early And Then Associates With The Growing Distal TipsRecruited To The Mother Centriole By Kif24Removed From Centrioles By Ttbk2Leading To Initiation Of Ciliogenesis And Localizes Only To The Daughter Centriole In Ciliated CellsIn Cytotoxic T Lymphocytes Remains Associated With The Mother Centriole During Docking Of The Centrosome At The Immunological Synapse Upon Target ContactRecruited At The Distal End Of The Mother Centriole By Mphosph9 |
| Alternative Antibody Names | Anti-Centriolar Coiled-Coil Protein Of 110 Kda antibodyAnti-Centrosomal Protein Of 110 Kda antibodyAnti-Cp110 antibodyAnti-Cep110 antibodyAnti-CCP110 antibodyAnti-CEP110 antibodyAnti-CP110 antibodyAnti-KIAA0419 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
