| Post Translational Modifications | Ubiquitinated.leading to its degradation. Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination. |
| Function | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. |
| Protein Name | Cyclin-YCyc-YCyclin Box Protein 1Cyclin Fold Protein 1Cyclin-X |
| Database Links | |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Y antibodyAnti-Cyc-Y antibodyAnti-Cyclin Box Protein 1 antibodyAnti-Cyclin Fold Protein 1 antibodyAnti-Cyclin-X antibodyAnti-CCNY antibodyAnti-C10orf9 antibodyAnti-CBCP1 antibodyAnti-CFP1 antibody |
Information sourced from Uniprot.org
