• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Anti-CCNT2 antibody (510-590 aa) (STJ193202)

SKU:
STJ193202

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cyclin-T2 (510-590 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
WB 1:500-2000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCNT2
Gene ID: 905
Uniprot ID: CCNT2_HUMAN
Immunogen Region: 510-590 aa
Specificity: This antibody detects endogenous levels of human Cyclin T2
Immunogen: Synthesized peptide derived from the human Cyclin T2 at the amino acid range 510-590
Function Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA. Plays a role during muscle differentiation.P-TEFB complex interacts with MYOD1.this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes.this event correlates with hyperphosphorylation of the CTD domain of RNA pol II. In addition, enhances MYOD1-dependent transcription through interaction with PKN1. Involved in early embryo development. (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters.
Protein Name Cyclin-T2
Cyct2
Database Links Reactome: R-HSA-112382
Reactome: R-HSA-167152
Reactome: R-HSA-167287
Reactome: R-HSA-167290
Reactome: R-HSA-2173796
Reactome: R-HSA-674695
Reactome: R-HSA-6796648
Reactome: R-HSA-6807505
Reactome: R-HSA-75955
Cellular Localisation Cytoplasm
Perinuclear Region
Nucleus
Nucleus In Differentiating Cells
Alternative Antibody Names Anti-Cyclin-T2 antibody
Anti-Cyct2 antibody
Anti-CCNT2 antibody

Information sourced from Uniprot.org

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