| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CCNT2 |
| Gene ID: |
905 |
| Uniprot ID: |
CCNT2_HUMAN |
| Immunogen Region: |
250-550 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human CCNT2 (NP_001232.1). |
| Immunogen Sequence: |
RLKKIRNWRANQAARKPKVD GQVSETPLLGSSLVQNSILV DSVTGVPTNPSFQKPSTSAF PAPVPLNSGNISVQDSHTSD NLSMLATGMPSTSYGLSSHQ EWPQHQDSARTEQLYSQKQE TSLSGSQYNINFQQGPSISL HSGLHHRPDKISDHSSVKQE YTHKAGSSKHHGPISTTPGI IPQKMSLDKYREKRKLETLD LDVRDHYIAAQVEQQHKQGQ SQAASSSSVTSPIKMKIPI |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA. Plays a role during muscle differentiation.P-TEFB complex interacts with MYOD1.this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes.this event correlates with hyperphosphorylation of the CTD domain of RNA pol II. In addition, enhances MYOD1-dependent transcription through interaction with PKN1. Involved in early embryo development. (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. |
| Protein Name | Cyclin-T2Cyct2 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-167152Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-2173796Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-6807505Reactome: R-HSA-75955 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusNucleus In Differentiating Cells |
| Alternative Antibody Names | Anti-Cyclin-T2 antibodyAnti-Cyct2 antibodyAnti-CCNT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
