| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Cyclin-H (1-323) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNH |
| Gene ID: | 902 |
| Uniprot ID: | CCNH_HUMAN |
| Immunogen Region: | 1-323 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human Cyclin H (NP_001230.1). |
| Immunogen Sequence: | MYHNSSQKRHWTFSSEEQLA RLRADANRKFRCKAVANGKV LPNDPVFLEPHEEMTLCKYY EKRLLEFCSVFKPAMPRSVV GTACMYFKRFYLNNSVMEYH PRIIMLTCAFLACKVDEFNV SSPQFVGNLRESPLGQEKAL EQILEYELLLIQQLNFHLIV HNPYRPFEGFLIDLKTRYPI LENPEILRKTADDFLNRIAL TDAYLLYTPSQIALTAILSS ASRAGITMESYLSESLMLK |
| Function | Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. |
| Protein Name | Cyclin-HMo15-Associated ProteinP34P37 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167160Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-167200Reactome: R-HSA-167246Reactome: R-HSA-427413Reactome: R-HSA-5696395Reactome: R-HSA-674695Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-6796648Reactome: R-HSA-69202Reactome: R-HSA-69231Reactome: R-HSA-69273Reactome: R-HSA-69656Reactome: R-HSA-72086Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-73863Reactome: R-HSA-75953Reactome: R-HSA-75955Reactome: R-HSA-76042Reactome: R-HSA-77075Reactome: R-HSA-8939236 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclin-H antibodyAnti-Mo15-Associated Protein antibodyAnti-P34 antibodyAnti-P37 antibodyAnti-CCNH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
