| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNE2 |
| Gene ID: | 9134 |
| Uniprot ID: | CCNE2_HUMAN |
| Immunogen Region: | 255-404 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 255-404 of human Cyclin E2 (NP_477097.1). |
| Immunogen Sequence: | ALKDAPKVLLPQYSQETFIQ IAQLLDLCILAIDSLEFQYR ILTAAALCHFTSIEVVKKAS GLEWDSISECVDWMVPFVNV VKSTSPVKLKTFKKIPMEDR HNIQTHTNYLAMLEEVNYIN TFRKGGQLSPVCNGGIMTPP KSTEKPPGKH |
| Tissue Specificity | highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. : low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. |
| Post Translational Modifications | Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway. Lactylated at Lys-348. Delactylated by SIRT3. |
| Function | Essential for the control of the cell cycle at the late G1 and early S phase. |
| Protein Name | G1/S-Specific Cyclin-E2 |
| Database Links | Reactome: R-HSA-1538133Reactome: R-HSA-187577Reactome: R-HSA-2559586Reactome: R-HSA-390471Reactome: R-HSA-6804116Reactome: R-HSA-69017Reactome: R-HSA-69200Reactome: R-HSA-69202Reactome: R-HSA-69231Reactome: R-HSA-69563Reactome: R-HSA-9661069 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-G1/S-Specific Cyclin-E2 antibodyAnti-CCNE2 antibody |
Information sourced from Uniprot.org