• Immunohistochemistry analysis of paraffin-embedded mouse heart using CCM2 antibody (STJ28627) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded rat heart using CCM2 antibody (STJ28627) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human liver using CCM2 antibody (STJ28627) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of extracts of MCF7 cells, using CCM2 antibody (STJ28627) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-CCM2 antibody (1-300) (STJ28627)

SKU:
STJ28627

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CCM2 (1-300) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCM2
Gene ID: 83605
Uniprot ID: CCM2_HUMAN
Immunogen Region: 1-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CCM2 (NP_113631.1).
Immunogen Sequence: MEEEGKKGKKPGIVSPFKRV FLKGEKSRDKKAHEKVTERR PLHTVVLSLPERVEPDRLLS DYIEKEVKYLGQLTSIPGYL NPSSRTEILHFIDNAKRAHQ LPGHLTQEHDAVLSLSAYNV KLAWRDGEDIILRVPIHDIA AVSYVRDDAAHLVVLKTAQD PGISPSQSLCAESSRGLSAG SLSESAVGPVEACCLVILAA ESKVAAEELCCLLGQVFQVV YTESTIDFLDRAIFDGAST
Function Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
Protein Name Cerebral Cavernous Malformations 2 Protein
Malcavernin
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Cerebral Cavernous Malformations 2 Protein antibody
Anti-Malcavernin antibody
Anti-CCM2 antibody
Anti-C7orf22 antibody
Anti-PP10187 antibody

Information sourced from Uniprot.org

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