| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCL25 |
| Gene ID: | 6370 |
| Uniprot ID: | CCL25_HUMAN |
| Immunogen Region: | 24-150 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-150 of human CCL25 (NP_005615.2). |
| Immunogen Sequence: | QGVFEDCCLAYHYPIGWAVL RRAWTYRIQEVSGSCNLPAA IFYLPKRHRKVCGNPKSREV QRAMKLLDARNKVFAKLHHN TQTFQAGPHAVKKLSSGNSK LSSSKFSNPISSSKRNVSLL ISANSGL |
| Tissue Specificity | Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine. |
| Function | Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Protein Name | C-C Motif Chemokine 25Chemokine TeckSmall-Inducible Cytokine A25Thymus-Expressed Chemokine |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 25 antibodyAnti-Chemokine Teck antibodyAnti-Small-Inducible Cytokine A25 antibodyAnti-Thymus-Expressed Chemokine antibodyAnti-CCL25 antibodyAnti-SCYA25 antibodyAnti-TECK antibody |
Information sourced from Uniprot.org