| Post Translational Modifications | O-glycosylated, with additional sialic acid modifications. |
| Function | Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding. In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1. In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine-like function. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated histone acetyltransferase activity. Has a critical role in the regulation of osteogenesis and bone development. |
| Protein Name | Coiled-Coil Domain-Containing Protein 134 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum LumenSecretedCytoplasmNucleusMainly Localizes To The Endoplasmic ReticulumAccumulates In The Nucleus In Response To Uv Irradiation |
| Alternative Antibody Names | Anti-Coiled-Coil Domain-Containing Protein 134 antibodyAnti-CCDC134 antibody |
Information sourced from Uniprot.org
