| Post Translational Modifications | O-glycosylated, with additional sialic acid modifications. |
| Function | In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. Has a critical role in the regulation of osteogenesis and bone development. In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. |
| Protein Name | Coiled-Coil Domain-Containing Protein 134 |
| Cellular Localisation | NucleusCytoplasmSecretedEndoplasmic ReticulumAccumulates In The Nucleus In Response To Uv Irradiation |
| Alternative Antibody Names | Anti-Coiled-Coil Domain-Containing Protein 134 antibodyAnti-CCDC134 antibody |
Information sourced from Uniprot.org
