| Short Description : | Rabbit polyclonal Chromobox Protein Homolog 7 (162-251) antibody for use in WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000 |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CBX7 |
| Gene ID: | 23492 |
| Uniprot ID: | CBX7_HUMAN |
| Immunogen Region: | 162-251 |
| Immunogen Sequence: | NLESHSHRRELFLQEPPAPD VLQAAGEWEPAAQPPEEEAD ADLAEGPPPWTPALPSSEVT VTDITANSITVTFREAQAAE GFFRDRSGKF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 162-251 of human CBX7 (NP_783640.1). |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. |
| Protein Name | Chromobox Protein Homolog 7 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Chromobox Protein Homolog 7 antibodyAnti-CBX7 antibody |
Information sourced from Uniprot.org
