| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CBR4 (1-237) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CBR4 |
| Gene ID: |
84869 |
| Uniprot ID: |
CBR4_HUMAN |
| Immunogen Region: |
1-237 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human CBR4 (NP_116172.2). |
| Immunogen Sequence: |
MDKVCAVFGGSRGIGRAVAQ LMARKGYRLAVIARNLEGAK AAAGDLGGDHLAFSCDVAKE HDVQNTFEELEKHLGRVNFL VNAAGINRDGLLVRTKTEDM VSQLHTNLLGSMLTCKAAMR TMIQQQGGSIVNVGSIVGLK GNSGQSVYSASKGGLVGFSR ALAKEVARKKIRVNVVAPGF VHTDMTKDLKEEHLKKNIPL GRFGETIEVAHAVVFLLESP YITGHVLVVDGGLQLIL |
| Tissue Specificity | Detected in liver and kidney (at protein level). Displays the highest expression in neuronal and muscle tissues. |
| Function | Component of the heterotetramer complex KAR (3-ketoacyl-acyl carrier protein reductase or 3-ketoacyl-ACP reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-ACP to (3R)-hydroxyacyl-ACP in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). |
| Protein Name | 3-Oxoacyl-Acyl-Carrier-Protein Reductase3-Ketoacyl-Acyl-Carrier-Protein Reductase Beta SubunitKar Beta SubunitCarbonyl Reductase Family Member 4Cbr4Quinone Reductase Cbr4Short Chain Dehydrogenase/Reductase Family 45c Member 1 |
| Database Links | Reactome: R-HSA-75105 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-3-Oxoacyl-Acyl-Carrier-Protein Reductase antibodyAnti-3-Ketoacyl-Acyl-Carrier-Protein Reductase Beta Subunit antibodyAnti-Kar Beta Subunit antibodyAnti-Carbonyl Reductase Family Member 4 antibodyAnti-Cbr4 antibodyAnti-Quinone Reductase Cbr4 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 45c Member 1 antibodyAnti-CBR4 antibodyAnti-SDR45C1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
