Anti-CBR1 antibody (181-230 aa) (STJ91997)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CBR1 at the amino acid range 181-230
General Information
| Short Description | Rabbit polyclonal anti-Carbonyl reductase 1+ CBR1 9-reductase (181-230 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBR1 |
| Gene ID | 873 |
| Uniprot ID | CBR1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CBR1 at the amino acid range 181-230 |
| Immunogen Region | 181-230 aa |
| Specificity | Carbonyl Reductase 1 Polyclonal Antibody detects endogenous levels of Carbonyl Reductase 1 protein. |
Additional Info
| Function | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue. |
| Protein Name | Carbonyl Reductase Nadph 115-Hydroxyprostaglandin Dehydrogenase Nadp(+20-Beta-Hydroxysteroid DehydrogenaseAlcohol Dehydrogenase Nad(P+ Cbr1Nadph-Dependent Carbonyl Reductase 1Prostaglandin 9-KetoreductasePg-9-KrProstaglandin-E(2 9-ReductaseShort Chain Dehydrogenase/Reductase Family 21c Member 1 |
| Database Links | Reactome: R-HSA-2162123 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Carbonyl Reductase Nadph 1 antibodyAnti-15-Hydroxyprostaglandin Dehydrogenase Nadp(+ antibodyAnti-20-Beta-Hydroxysteroid Dehydrogenase antibodyAnti-Alcohol Dehydrogenase Nad(P+ Cbr1 antibodyAnti-Nadph-Dependent Carbonyl Reductase 1 antibodyAnti-Prostaglandin 9-Ketoreductase antibodyAnti-Pg-9-Kr antibodyAnti-Prostaglandin-E(2 9-Reductase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 21c Member 1 antibodyAnti-CBR1 antibodyAnti-CBR antibodyAnti-CRN antibodyAnti-SDR21C1 antibody |
Information sourced from Uniprot.org