Anti-CBFA2T3 antibody (593-653) (STJ116912)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CBFA2T3 (593-653) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBFA2T3 |
| Gene ID | 863 |
| Uniprot ID | MTG16_HUMAN |
| Immunogen Region | 593-653 |
| Immunogen Sequence | GQSLQGPTAVVADPVPGPPE AAHSLGPSLPVGAASPSEAG SAGPSRPGSPSPPGPLDTVP R |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 593-653 of human CBFA2T3 (NP_005178.4). |
Additional Info
| Tissue Specificity | Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level). |
| Function | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A.interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. Isoform 2 functions as an A-kinase-anchoring protein. |
| Protein Name | Protein Cbfa2t3Mtg8-Related Protein 2Myeloid Translocation Gene On Chromosome 16 ProteinHmtg16Zinc Finger Mynd Domain-Containing Protein 4 |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusNucleolusThe Runx1-Cbfa2t3 Fusion Protein Localizes To The NucleoplasmIsoform 2: NucleusNucleoplasmGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Protein Cbfa2t3 antibodyAnti-Mtg8-Related Protein 2 antibodyAnti-Myeloid Translocation Gene On Chromosome 16 Protein antibodyAnti-Hmtg16 antibodyAnti-Zinc Finger Mynd Domain-Containing Protein 4 antibodyAnti-CBFA2T3 antibodyAnti-MTG16 antibodyAnti-MTGR2 antibodyAnti-ZMYND4 antibody |
Information sourced from Uniprot.org