| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:5000-1:30000IHC-P:1:500-1:2000IF/ICC:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
IGF2R |
| Gene ID: |
3482 |
| Uniprot ID: |
MPRI_HUMAN |
| Immunogen Region: |
2140-2300 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 2140-2300 of human Cation-independent M6PR (IGF2R) (NP_000867.3). |
| Immunogen Sequence: |
TNPINGKSFSLGDIYFKLFR ASGDMRTNGDNYLYEIQLSS ITSSRNPACSGANICQVKPN DQHFSRKVGTSDKTKYYLQD GDLDVVFASSSKCGKDKTKS VSSTIFFHCDPLVEDGIPEF SHETADCQYLFSWYTSAVCP LGVGFDSENPGDDGQMHKGL S |
| Post Translational Modifications | Palmitoylated. Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus. |
| Function | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. |
| Protein Name | Cation-Independent Mannose-6-Phosphate ReceptorCi Man-6-P ReceptorCi-MprM6pr300 Kda Mannose 6-Phosphate ReceptorMpr 300Insulin-Like Growth Factor 2 ReceptorInsulin-Like Growth Factor Ii ReceptorIgf-Ii ReceptorM6p/Igf2 ReceptorM6p/Igf2rCd Antigen Cd222 |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-6798695Reactome: R-HSA-6811440Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneMainly Localized In The Golgi At Steady State And Not Detectable In LysosomeColocalized With Dpp4 In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface |
| Alternative Antibody Names | Anti-Cation-Independent Mannose-6-Phosphate Receptor antibodyAnti-Ci Man-6-P Receptor antibodyAnti-Ci-Mpr antibodyAnti-M6pr antibodyAnti-300 Kda Mannose 6-Phosphate Receptor antibodyAnti-Mpr 300 antibodyAnti-Insulin-Like Growth Factor 2 Receptor antibodyAnti-Insulin-Like Growth Factor Ii Receptor antibodyAnti-Igf-Ii Receptor antibodyAnti-M6p/Igf2 Receptor antibodyAnti-M6p/Igf2r antibodyAnti-Cd Antigen Cd222 antibodyAnti-IGF2R antibodyAnti-MPRI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
