| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cytosolic arginine sensor for mTORC1 subunit 2 (79-129 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CASTOR2 |
| Gene ID: |
729438 |
| Uniprot ID: |
CAST2_HUMAN |
| Immunogen Region: |
79-129 aa |
| Specificity: |
This antibody detects endogenous levels of GATL2 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human GATL2 at the amino acid range 79-129 |
| Function | Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. |
| Protein Name | Cytosolic Arginine Sensor For Mtorc1 Subunit 2Cellular Arginine Sensor For Mtorc1 Protein 2Gats-Like Protein 2 |
| Database Links | Reactome: R-HSA-9639288 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Cytosolic Arginine Sensor For Mtorc1 Subunit 2 antibodyAnti-Cellular Arginine Sensor For Mtorc1 Protein 2 antibodyAnti-Gats-Like Protein 2 antibodyAnti-CASTOR2 antibodyAnti-GATSL1 antibodyAnti-GATSL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
