| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation at Ser-14 by AKT1, promoting the interaction between CASTOR1 and RNF167. Ubiquitinated by RNF167 via 'Lys-29'-polyubiquitination, leading to its degradation, releasing the GATOR2 complex. Ubiquitination by RNF167 is promoted by phosphorylation at Ser-14 by AKT1. |
| Function | Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. |
| Protein Name | Cytosolic Arginine Sensor For Mtorc1 Subunit 1Cellular Arginine Sensor For Mtorc1 Protein 1Gats-Like Protein 3 |
| Database Links | Reactome: R-HSA-9639288 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Cytosolic Arginine Sensor For Mtorc1 Subunit 1 antibodyAnti-Cellular Arginine Sensor For Mtorc1 Protein 1 antibodyAnti-Gats-Like Protein 3 antibodyAnti-CASTOR1 antibodyAnti-GATSL3 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and CRYZ knockout (KO) HeLa cells, using [KO Validated] CRYZ Rabbit polyclonal antibody (STJ11100873) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89807/358274/STJ11100873_1__03594.1713122620.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and CRYZ knockout (KO) HeLa cells, using [KO Validated] CRYZ Rabbit polyclonal antibody (STJ11100873) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.")
