| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CASP8AP2 |
| Gene ID: | 9994 |
| Uniprot ID: | C8AP2_HUMAN |
| Immunogen Region: | 1733-1982 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1733-1982 of human CASP8AP2 (NP_036247.1). |
| Immunogen Sequence: | TVGAFIDLTQDASSEAKSEG NHPALAVEDLGCGVIQVDED NCKEEKAQVANRPLKCIVEE TYIDLTTESPSSCEVKKDEL KSEPGSNCDNSELPGTLHNS HKKRRNISDLNHPHKKQRKE TDLTNKEKTKKPTQDSCENT EAHQKKASKKKAPPVTKDPS SLKATPGIKDSSAALATSTS LSAKNVIKKKGEIIILWTRN DDREILLECQKRGPSFKTFA YLAAKLDKNPNQVSERFQQ |
| Function | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. |
| Protein Name | Casp8-Associated Protein 2Flice-Associated Huge Protein |
| Database Links | Reactome: R-HSA-3899300 |
| Cellular Localisation | CytoplasmNucleusPml BodyMitochondrionExported From The Nucleus To The Mitochondria Upon Fas Activation |
| Alternative Antibody Names | Anti-Casp8-Associated Protein 2 antibodyAnti-Flice-Associated Huge Protein antibodyAnti-CASP8AP2 antibodyAnti-FLASH antibodyAnti-KIAA1315 antibodyAnti-RIP25 antibody |
Information sourced from Uniprot.org