| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-cardiolipin synthase 1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 30kDa band observed in lysates of cell line HEK293 (calculated MW of 32.6kDa according to NP_061968.1). Recommended concentration: 0.2-0.6µg/ml. Primary incubation was 1 hour. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CRLS1 |
| Gene ID: | 54675 |
| Uniprot ID: | CRLS1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_061968.1; NP_001120930.1 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_061968.1; NP_001120930.1). |
| Immunogen Sequence: | RSALGSALDPLADK |
| Function | Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. |
| Protein Name | Cardiolipin SynthaseCmp-FormingClsProtein Gcd10 Homolog |
| Database Links | Reactome: R-HSA-1482925Reactome: R-HSA-1483076 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cardiolipin Synthase antibodyAnti-Cmp-Forming antibodyAnti-Cls antibodyAnti-Protein Gcd10 Homolog antibodyAnti-CRLS1 antibodyAnti-C20orf155 antibodyAnti-CLS1 antibody |
Information sourced from Uniprot.org