| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CARD14 |
| Gene ID: | 79092 |
| Uniprot ID: | CAR14_HUMAN |
| Immunogen Region: | 200-500 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human CARD14 (NP_001244899.1). |
| Immunogen Sequence: | SLSLHYSNALQEKELAASRC RSLQEELYLLKQELQRANMV SSCELELQEQSLRTASDQES GDEELNRLKEENEKLRSLTF SLAEKDILEQSLDEARGSRQ ELVERIHSLRERAVAAERQR EQYWEEKEQTLLQFQKSKMA CQLYREKVNALQAQVCELQK ERDQAYSARDSAQREISQSL VEKDSLRRQVFELTDQVCEL RTQLRQLQAEPPGVLKQEAR TREPCPREKQRLVRMHAIC |
| Tissue Specificity | Isoform 1 is detected in placenta and epidermal keratinocytes. Isoform 2 is detected in leukocytes and fetal brain. |
| Function | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Isoform 3: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator. |
| Protein Name | Caspase Recruitment Domain-Containing Protein 14Card-Containing Maguk Protein 2Carma 2 |
| Cellular Localisation | Isoform 1: CytoplasmIsoform 2: CytoplasmIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Caspase Recruitment Domain-Containing Protein 14 antibodyAnti-Card-Containing Maguk Protein 2 antibodyAnti-Carma 2 antibodyAnti-CARD14 antibodyAnti-CARMA2 antibody |
Information sourced from Uniprot.org