Anti-Carbonyl reductase 3/CBR3 antibody (1-277aa) [AT7E8] (STJA0041550)

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STJA0041550
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: ELISA/WB/ICC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-Carbonyl reductase 3/CBR3 (1-277aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : AT7E8
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol
Purification: By protein-G affinity chromatography
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CBR3
Gene ID: 874
Uniprot ID: CBR3_HUMAN
Immunogen Region: 1-277aa
Accession Number: NP_001227
Immunogen: Recombinant human CBR3 (1-277aa) purified from E. coli
Tissue Specificity Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.
Function Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified.
Protein Name Carbonyl Reductase Nadph 3
Nadph-Dependent Carbonyl Reductase 3
Quinone Reductase Cbr3
Short Chain Dehydrogenase/Reductase Family 21c Member 2
Database Links Reactome: R-HSA-211945
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Carbonyl Reductase Nadph 3 antibody
Anti-Nadph-Dependent Carbonyl Reductase 3 antibody
Anti-Quinone Reductase Cbr3 antibody
Anti-Short Chain Dehydrogenase/Reductase Family 21c Member 2 antibody
Anti-CBR3 antibody
Anti-SDR21C2 antibody

Information sourced from Uniprot.org

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