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Anti-CAPZB antibody (1-272) (STJ110405)

Western blot analysis of extracts of various cell lines, using CAPZB antibody (STJ110405) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Immunofluorescence analysis of U2OS cells using CAPZB antibody (STJ110405) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of U2OS cells using CAPZB antibody (STJ110405) at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using CAPZB antibody (STJ110405) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-CAPZB antibody (1-272) (STJ110405)

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STJ110405

£112.50 - £522.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CAPZB (1-272) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CAPZB
Gene ID:	832
Uniprot ID:	CAPZB_HUMAN
Immunogen Region:	1-272
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human CAPZB (NP_004921.1).
Immunogen Sequence:	MSDQQLDCALDLMRRLPPQQ IEKNLSDLIDLVPSLCEDLL SSVDQPLKIARDKVVGKDYL LCDYNRDGDSYRSPWSNKYD PPLEDGAMPSARLRKLEVEA NNAFDQYRDLYFEGGVSSVY LWDLDHGFAGVILIKKAGDG SKKIKGCWDSIHVVEVQEKS SGRTAHYKLTSTVMLWLQTN KSGSGTMNLGGSLTRQMEKD ETVSDCSPHIANIGRLVEDM ENKIRSTLNEIYFGKTKDI

Function	F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
Protein Name	F-Actin-Capping Protein Subunit Beta Capz Beta
Database Links	Reactome: R-HSA-2132295 Reactome: R-HSA-3371497 Reactome: R-HSA-6807878 Reactome: R-HSA-6811436 Reactome: R-HSA-9013405 Reactome: R-HSA-9035034 Reactome: R-HSA-9662360 Reactome: R-HSA-983231
Cellular Localisation	Cytoplasm Cytoskeleton Myofibril Sarcomere
Alternative Antibody Names	Anti-F-Actin-Capping Protein Subunit Beta antibody Anti-Capz Beta antibody Anti-CAPZB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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