| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CAPN6 (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CAPN6 |
| Gene ID: |
827 |
| Uniprot ID: |
CAN6_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CAPN6 (NP_055104.2). |
| Immunogen Sequence: |
MGPPLKLFKNQKYQELKQEC IKDSRLFCDPTFLPENDSLF YNRLLPGKVVWKRPQDICDD PHLIVGNISNHQLTQGRLGH KPMVSAFSCLAVQESHWTKT IPNHKEQEWDPQKTEKYAGI FHFRFWHFGEWTEVVIDDLL PTINGDLVFSFSTSMNEFWN ALLEKAYAKLLGCYEALDGL TITDIIVDFTGTLAETVDMQ KGRYTELVEEKYKLFGELYK TFTKGGLICCSIESPNQEE |
| Tissue Specificity | Expressed only in placenta. |
| Function | Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. |
| Protein Name | Calpain-6Calpain-Like Protease X-LinkedCalpamodulinCalpm |
| Database Links | Reactome: R-HSA-1474228 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonSpindleDuring Mitose Associated With The Mitotic SpindleAt Telophase Colocalized To The Midbody Spindle |
| Alternative Antibody Names | Anti-Calpain-6 antibodyAnti-Calpain-Like Protease X-Linked antibodyAnti-Calpamodulin antibodyAnti-Calpm antibodyAnti-CAPN6 antibodyAnti-CALPM antibodyAnti-CANPX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
