| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAPN6 |
| Gene ID: | 827 |
| Uniprot ID: | CAN6_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CAPN6 (NP_055104.2). |
| Immunogen Sequence: | MGPPLKLFKNQKYQELKQEC IKDSRLFCDPTFLPENDSLF YNRLLPGKVVWKRPQDICDD PHLIVGNISNHQLTQGRLGH KPMVSAFSCLAVQESHWTKT IPNHKEQEWDPQKTEKYAGI FHFRFWHFGEWTEVVIDDLL PTINGDLVFSFSTSMNEFWN ALLEKAYAKLLGCYEALDGL TITDIIVDFTGTLAETVDMQ KGRYTELVEEKYKLFGELYK TFTKGGLICCSIESPNQEE |
| Tissue Specificity | Expressed only in placenta. |
| Function | Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. |
| Protein Name | Calpain-6Calpain-Like Protease X-LinkedCalpamodulinCalpm |
| Database Links | Reactome: R-HSA-1474228 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonSpindleDuring Mitose Associated With The Mitotic SpindleAt Telophase Colocalized To The Midbody Spindle |
| Alternative Antibody Names | Anti-Calpain-6 antibodyAnti-Calpain-Like Protease X-Linked antibodyAnti-Calpamodulin antibodyAnti-Calpm antibodyAnti-CAPN6 antibodyAnti-CALPM antibodyAnti-CANPX antibody |
Information sourced from Uniprot.org