| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Calpain-2 catalytic subunit (305-354 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAPN2 |
| Gene ID: | 824 |
| Uniprot ID: | CAN2_HUMAN |
| Immunogen Region: | 305-354 aa |
| Specificity: | Calpain 2 Polyclonal Antibody detects endogenous levels of Calpain 2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Calpain 2 at the amino acid range 305-354 |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. |
| Protein Name | Calpain-2 Catalytic SubunitCalcium-Activated Neutral Proteinase 2Canp 2Calpain M-TypeCalpain Large Polypeptide L2Calpain-2 Large SubunitMillimolar-CalpainM-Calpain |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-8862803Reactome: R-HSA-9856530Reactome: R-HSA-9860927 |
| Cellular Localisation | CytoplasmCell MembraneTranslocates To The Plasma Membrane Upon Ca(2+) Binding |
| Alternative Antibody Names | Anti-Calpain-2 Catalytic Subunit antibodyAnti-Calcium-Activated Neutral Proteinase 2 antibodyAnti-Canp 2 antibodyAnti-Calpain M-Type antibodyAnti-Calpain Large Polypeptide L2 antibodyAnti-Calpain-2 Large Subunit antibodyAnti-Millimolar-Calpain antibodyAnti-M-Calpain antibodyAnti-CAPN2 antibodyAnti-CANPL2 antibody |
Information sourced from Uniprot.org
