| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAPG |
| Gene ID: | 822 |
| Uniprot ID: | CAPG_HUMAN |
| Immunogen Region: | 1-348 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human CAPG (NP_001738.2). |
| Immunogen Sequence: | MYTAIPQSGSPFPGSVQDPG LHVWRVEKLKPVPVAQENQG VFFSGDSYLVLHNGPEEVSH LHLWIGQQSSRDEQGACAVL AVHLNTLLGERPVQHREVQG NESDLFMSYFPRGLKYQEGG VESAFHKTSTGAPAAIKKLY QVKGKKNIRATERALNWDSF NTGDCFILDLGQNIFAWCGG KSNILERNKARDLALAIRDS ERQGKAQVEIVTDGEEPAEM IQVLGPKPALKEGNPEEDL |
| Tissue Specificity | Macrophages and macrophage-like cells. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| Protein Name | Macrophage-Capping ProteinActin Regulatory Protein Cap-G |
| Cellular Localisation | NucleusCytoplasmMelanosomeCell ProjectionLamellipodiumRuffleIn MacrophagesMay Be Predominantly CytoplasmicNuclear Localization Was Observed In FibroblastsPresent At The Membrane-Cytoplasm InterfaceIn Activated MacrophagesConcentrated In The Ruffles Of The Leading Lamellipodia |
| Alternative Antibody Names | Anti-Macrophage-Capping Protein antibodyAnti-Actin Regulatory Protein Cap-G antibodyAnti-CAPG antibodyAnti-AFCP antibodyAnti-MCP antibody |
Information sourced from Uniprot.org