| Short Description : | Rabbit polyclonal CAND1 (750-980) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAND1 |
| Gene ID: | 55832 |
| Uniprot ID: | CAND1_HUMAN |
| Immunogen Region: | 750-980 |
| Immunogen Sequence: | GALSAMLDFFQALVVTGTNN LGYMDLLRMLTGPVYSQSTA LTHKQSYYSIAKCVAALTRA CPKEGPAVVGQFIQDVKNSR STDSIRLLALLSLGEVGHHI DLSGQLELKSVILEAFSSPS EEVKSAASYALGSISVGNLP EYLPFVLQEITSQPKRQYLL LHSLKEIISSASVVGLKPYV ENIWALLLKHCECAEEGTRN VVAECLGKLTLIDPETLLPR LKGYLISGSSY |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-980 of human CAND1 (NP_060918.2). |
| Function | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. |
| Protein Name | Cullin-Associated Nedd8-Dissociated Protein 1Cullin-Associated And Neddylation-Dissociated Protein 1Tbp-Interacting Protein Of 120 Kda ATbp-Interacting Protein 120aP120 Cand1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8951664Reactome: R-HSA-917937 |
| Cellular Localisation | CytoplasmNucleusPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Cullin-Associated Nedd8-Dissociated Protein 1 antibodyAnti-Cullin-Associated And Neddylation-Dissociated Protein 1 antibodyAnti-Tbp-Interacting Protein Of 120 Kda A antibodyAnti-Tbp-Interacting Protein 120a antibodyAnti-P120 Cand1 antibodyAnti-CAND1 antibodyAnti-KIAA0829 antibodyAnti-TIP120 antibodyAnti-TIP120A antibody |
Information sourced from Uniprot.org
